Thermo Fisher Scientific MSK1 Polyclonal Antibody
MSK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 적합. 액상 형태로 제공되며 4°C에서 보관. FFPE 조직에서 citrate buffer(pH 6.0)로 epitope retrieval 권장.
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Thermo Fisher Scientific MSK1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 752 and 802 of human Mitogen- and Stress-activated Protein Kinase 1 (MSK1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan.
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase essential for the regulation of various cellular processes.
It is required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, and regulates RELA, STAT3, and ETV1/ER81.
MSK1 contributes to gene activation by histone phosphorylation and regulates inflammatory genes.
It phosphorylates CREB1 and ATF1 in response to stimuli such as UV-C irradiation, EGF, and anisomycin.
MSK1 controls RELA transcriptional activity in response to TNF and interacts with the glucocorticoid receptor NR3C1 to repress inflammatory gene expression.
In skeletal myoblasts, it is required for RELA phosphorylation at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it mediates Ser-727 phosphorylation of STAT3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: A302-747A-M_MSK1_O75582-1_Rabbit.svg, A302-747A-M_MSK1_O75582-1_Rabbit_PDP.jpeg)
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