Thermo Fisher Scientific CD74 Polyclonal Antibody, MaxPab

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQSHW NWRTRLLGWV

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the two extracellular domains
• Exon 4 encodes the transmembrane domain and the cytoplasmic tail

DRA does not have polymorphisms in the peptide-binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. Within the DR molecule, the beta chain contains all the polymorphisms specifying the peptide-binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The DR, DQ, and DP loci encode the major expressed products of the human class II region. These molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in the initiation of the immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.