Thermo Fisher Scientific GFAP Polyclonal Antibody, Biotin

Thermo Fisher Scientific GFAP Polyclonal Antibody, Biotin

Applications and Tested Dilution

Product Specifications

Target Information

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. It is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. Neural stem cells also strongly express GFAP.
Antibodies to GFAP are useful as markers of astrocytic cells and are heavily expressed in many types of brain tumors derived from astrocytic cells. GFAP is also found in the lens epithelium, Kupffer cells of the liver, certain salivary tumor cells, and has been reported in erythrocytes.
GFAP serves as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.