Thermo Fisher Scientific KMT2E Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
TYSQEGYDRS STMLTLGPFR NSNLTELGLQ EIKTIGYTSP RSRTEVNRQC PGEKEPVSDL QLGLDAVEPT ALHKTLETPA HDRAEPNSQL DSTH

Sequence identity:

• Mouse: 87%
• Rat: 89%

Target Information

The mixed lineage leukemia (MLL) gene family comprises a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias.

MLL2 (also designated ALR) exists within a complex of proteins and is important for mouse embryonic development. It may be involved in adhesion-related cytoskeletal events affecting cell growth and survival. The MLL2 gene maps to the human locus 19q13.1, a frequent target of rearrangement or amplification in solid tumors.

MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes. MLL3 maps to human chromosome 7, often deleted in myeloid disorders. MLL3 shows higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus. MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression. The human MLL5 gene lies within chromosome band 7q22.3, a region deleted in acute myeloid malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.