Thermo Fisher Scientific HLA-DR Monoclonal Antibody (CC108)

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Available Formats

• FITC
• PE
• Request custom conjugation

Product Specific Information

Mouse anti Bovine MHC class II DQ antibody, clone CC158 recognizes Bovine MHC Class II DQ.
MHC Class II molecules are constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, and activated T lymphocytes.
They may be induced on a range of other cell types by interferon gamma.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, without polymorphisms in the peptide-binding region.
The beta chain contains all polymorphisms specifying peptide binding specificities.
Hundreds of DRB1 alleles have been described, and typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in the initiation of the immune response.

HLA and MHC antibodies are essential tools in Immunopeptidomics, supporting the identification and characterization of neoantigens via high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.