Thermo Fisher Scientific c-Fos Monoclonal Antibody (CL6381)
인간 c-Fos 단백질을 인식하는 마우스 단클론 항체입니다. Western blot에 최적화되어 있으며, 1 µg/mL 농도로 사용 가능합니다. Protein A로 정제된 액상 항체로, PBS와 글리세롤 완충액에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL6381 |
| Immunogen | Synthetic peptide corresponding to Human c-Fos (amino acids 233–250) |
| Immunogen sequence | PESEEAFTLP LLNDPEPK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.00 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2848939 |
Product Specific Information
Immunogen sequence: PESEEAFTLP LLNDPEPK
Target Information
FBJ murine osteosarcoma viral oncogene homolog, commonly known as Cellular proto-oncogene Fos (c-Fos), belongs to the Fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14.
c-Fos forms a heterodimer with c-Jun to create the Activator Protein-1 (AP-1) transcription factor, which regulates genes involved in cellular signal transduction, proliferation, and differentiation.
It can be phosphorylated by various stimuli including growth factors and insulin at multiple sites. The ERK MAPK kinase phosphorylates c-Fos at Threonine 232, influencing its nuclear localization and transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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