Thermo Fisher Scientific TGIF Polyclonal Antibody
Western blot 및 ICC/IF에 사용 가능한 Rabbit polyclonal TGIF 항체. 인간 TGIF 단백질에 특이적으로 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TGIF. Recombinant protein control fragment (Product # RP-105224) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2663358 |
Product Specific Information
Immunogen sequence:
SVLARPSVICH TTVTALKDVP FSLCQSVGVG QNTDIQQIAA KNFTDTSLMY PEDTCKSGPS TNTQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 77%
Target Information
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This homeodomain binds to a retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. TGIF inhibits 9-cis-retinoic acid-dependent RXRα transcription activation and acts as a transcriptional co-repressor of SMAD2. It is involved in nuclear signaling during development and in adulthood. Mutations are associated with holoprosencephaly type 4, a structural brain anomaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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