ELK Biotechnology Recombinant Human FKBP4 (C-6His)
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| Product name: | Recombinant Human FKBP4 (C-6His) |
| Description: | Recombinant Human 52 kDa FK506 Binding Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala459 is expressed with a 6His tag at the C-terminus. |
| Expression Host: | E.coli |
| Accession: | Q02790 |
| Molecular weight: | 52.8 KDa |
| Apparent molecular weight: | 50-60 KDa, reducing conditions |
| Other names: | Peptidyl-prolyl cis-trans isomerase FKBP4; 51kDa FK506-binding protein; 51kDa FK506-binding protein; 59kDa immunophilin; FK506-binding protein 4; FKBP59; HSP-binding immunophilin; immunophilin FKBP52; Rotamase; FKBP4 |
| FORMULATION: | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0. |
| Purity: | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin: | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Storage: | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| Delivery condition: | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
| Background: | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
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