ELK Biotechnology Recombinant Human RGMA (N-6His)
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| Product name: | Recombinant Human RGMA (N-6His) |
| Description: | Recombinant Human Repulsive Guidance Molecule A is produced by our E.coli expression system and the target gene encoding Pro169-Gly422 is expressed with a 6His tag at the N-terminus. |
| Expression Host: | E.coli |
| Accession: | AAI51133.1 |
| Molecular weight: | 29.8 KDa |
| Apparent molecular weight: | 30 KDa, reducing conditions |
| Other names: | Repulsive guidance molecule A; RGM domain family member A; RGM |
| FORMULATION: | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 150mM NaCl, 1mM EDTA, pH 8.0. |
| Purity: | Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin: | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Storage: | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| Delivery condition: | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
| Background: | Repulsive guidance molecule A（RGMA） is a cell membrane protein and belongs to the repulsive guidance molecule (RGM) family. It interacts with NEO1, BMP2 and BMP4. RGMA is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. This protein may also function as a tumor suppressor in some cancers. |
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