Thermo Fisher Scientific SHANK2 Polyclonal Antibody
SHANK2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot에 최적화되어 있습니다. 인간 SHANK2 내부 영역에서 유래한 합성 펩타이드를 면역원으로 사용하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human SHANK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556034 |
Target Information
The SHANK2 gene encodes a protein that belongs to the Shank family of synaptic proteins, functioning as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins include multiple domains for protein-protein interactions such as ankyrin repeats and an SH3 domain. This family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides, and a sterile alpha motif.
Alternative splicing in Shank genes regulates the molecular structure and interaction profile of Shank proteins in the adult and developing brain. Mutations or alterations in SHANK2 may be associated with susceptibility to autism spectrum disorder. Multiple transcript variants are produced through alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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