Thermo Fisher Scientific Human SnoN Synthetic Peptide
인간 SnoN 단백질의 N-말단 16개 아미노산에 해당하는 합성 펩타이드입니다. 항체 PA5-20306과 함께 블로킹 펩타이드로 사용 가능합니다. PBS 버퍼 내 0.1% BSA와 0.02% sodium azide 포함, -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human SnoN.
PEP-0400 can be used as a blocking peptide with polyclonal antibody PA5-20306.
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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