Thermo Fisher Scientific SNX15 Polyclonal Antibody

Applications

• Western Blot (WB): 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93%; Dog: 93%; Goat: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%

Target Information

This gene encodes a member of the sorting nexin family. Members of this family contain a phox domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors.
This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.