Thermo Fisher Scientific MATN2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: AVGVGKAIEE ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED
• Storage recommendation:
  • Short term: 2–8°C up to 1 week
  • Long term: -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 91%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 82%

Target Information

Matrilin (MATNs) are a family of non-collagenous extracellular matrix proteins consisting of four known members that play key roles in forming both collagen-dependent and collagen-independent filamentous networks. The matrilin family shares structural domains including von Willebrand factor A domains, epidermal growth factor-like domains, and a coiled coil alpha-helical module.

MATN1 and MATN3 are mainly expressed in cartilage, while MATN2 and MATN4 occur in a wide variety of extracellular matrices. The matrilin genes are strictly and differently regulated, and their expression may serve as markers for cellular differentiation and diseases such as astrocytoma and liver carcinoma.

Recent studies show that MATN2 is a permissive substrate for axonal growth and cell migration, and it is required for successful nerve regeneration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.