Thermo Fisher Scientific PPP1R1A Polyclonal Antibody
PPP1R1A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 완충액(0.2% 젤라틴, 0.05% sodium azide)에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Horse, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 50–100 of human IPP-1 was used as the immunogen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2718856 |
Target Information
Protein phosphatase inhibitor-1 (also designated inhibitor of protein phosphatase 1, IPP-1 and I-1) regulates the phosphorylation of other proteins and is phosphorylated by cyclic AMP-dependent protein kinase at Threonine 35.
Proline-directed kinases Cdk1, Cdk5, and MAPK mediate in vitro phosphorylation of IPP-1 at Serine 67.
In striatal tissues, glutamate-dependent regulation of NMDA-type channels influences IPP-1 phosphorylation at Ser 67.
Localization and expression of IPP-1 suggest discrete roles in specific brain regions and developmental stages, independent of PP-1 regulation.
PP-1 binds both phosphorylated and dephosphorylated IPP-1, and conversion to a Mn++-dependent state may be involved in regulation by IPP-1.
IPP-1 attenuates glycogen phosphorylase activity and is implicated in hormonal control of glycogen metabolism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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