Thermo Fisher Scientific Tau protein Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures.

Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome. Short isoforms of Tau provide cytoskeletal plasticity, while longer isoforms contribute to stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which are the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD). Hyper-phosphorylation impairs Tau’s microtubule binding function, leading to microtubule destabilization and neuronal degeneration.

Several kinases phosphorylate Tau, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.