Thermo Fisher Scientific Phospho-TAK1 (Thr184) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated TAK1 (Thr184). Validated for Western blot (1:500–1:1,000). Targets human TAK1 involved in multiple signaling pathways including TGF-β and NF-κB. Supplied as liquid, unconjugated form at 1 mg/mL, sto...
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Thermo Fisher Scientific Phospho-TAK1 (Thr184) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184 (I-Q-TP-H-M) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555308 |
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling pathways, and responds to thyroid hormone, osmotic stress, endothelin, and ephrine.
TAK1 contributes to wound healing by regulating von Hippel-Lindau tumor suppressor expression and repressing PDGF-B and integrins β1/β5. It plays an essential role in IKK activation in pathways involving IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination, during which TAK1 undergoes autophosphorylation at Thr178, Thr184, Thr187, and Ser192 before phosphorylating IKK-β. TAK1 also represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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