Thermo Fisher Scientific PRPF40A Polyclonal Antibody
PRPF40A 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC(P), ICC/IF에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS buffer(40% glycerol) 보존, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PRPF40A. Recombinant protein control fragment (Product #RP-96227). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645975 |
Product Specific Information
Immunogen sequence:
NASTSASNTV SGTVPVVPEP EVTSIVATVV DNENTVTIST EEQAQLTSTP AIQDQSVEVS SNTGEETSKQ ETVADFTP
Sequence identity:
- Mouse: 76%
- Rat: 73%
Target Information
FNBP3 (Formin-binding protein 3) is a 957 amino acid protein encoded by the human gene PRPF40A. It belongs to the PRPF40 family and contains five FF domains and two WW domains. Nuclear proteins with both WW and FF interaction modules bind to splicing factors and RNA polymerase II, linking transcription with splicing.
FNBP3 binds to the Formin proline-rich regions through WW domains and interacts with WASL/N-WASP complex, suppressing its cytoplasmic translocation and function. It is widely expressed in most tissues and localized to nuclear speckles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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