Thermo Fisher Scientific CRIM1 Polyclonal Antibody
인간 CRIM1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:25~1:100 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보존. 조직 발달 및 신경 분화 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human cysteine rich transmembrane BMP regulator 1 (chordin-like) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636096 |
Product Specific Information
The antibody detects endogenous levels of total CRIM1 protein.
Target Information
CRIM1 (cysteine-rich motor neuron 1) is a glycosylated type I transmembrane protein involved in tissue development, including capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. It is developmentally expressed in tissues such as pancreas, kidney, placenta, brain, and blood vessels, and may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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