Thermo Fisher Scientific DAND5 Monoclonal Antibody (OTI2H3)
DAND5 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Flow cytometry에 적합합니다. Human 시료 반응성이 있으며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관 권장됩니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 23–189 of DAND5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.04 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723044 |
Target Information
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers.
The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring.
The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins.
As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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