Thermo Fisher Scientific SCUBE1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SCUBE1. Recombinant protein control fragment (Product #RP-91518).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647037

Product Specific Information

Immunogen sequence: EVSHITAEFE IETKMEEASD TCEADCLRKR AEQSLQAAIK TLRKSIGRQQ FYVQVSGTEY EVAQRPAKAL EGQGACGAGQ VLQDSKCVAC GPGTHFGGEL GQCVPCMPGT YQDMEGQLSC TPCPSSDGLG LPGARNVSEC GGKC

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.

Target Information

SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.