Thermo Fisher Scientific SCUBE1 Polyclonal Antibody
인간 SCUBE1 단백질에 특이적인 Rabbit Polyclonal 항체로, IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용 가능.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SCUBE1. Recombinant protein control fragment (Product #RP-91518) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647037 |
Product Specific Information
Immunogen sequence:
EVSHITAEFE IETKMEEASD TCEADCLRKR AEQSLQAAIK TLRKSIGRQQ FYVQVSGTEY EVAQRPAKAL EGQGACGAGQ VLQDSKCVAC GPGTHFGGEL GQCVPCMPGT YQDMEGQLSC TPCPSSDGLG LPGARNVSEC GGKC
Highest antigen sequence identity to orthologs:
- Mouse: 82%
- Rat: 83%
Target Information
SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm, and limb buds.
The N-terminal EGF-like repeats of SCUBE1 participate in Ca²⁺-dependent adhesion formation.
The C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity. Genetic ablation of this region in mice results in brain malformation, suggesting a role in brain morphogenesis.
SCUBE1 is also implicated in early craniofacial development in mice.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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