Thermo Fisher Scientific PAK3 Monoclonal Antibody (4G8A5)
Human PAK3 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot 및 ELISA에 사용 가능. 정제된 recombinant fragment(AA 1-100)를 면역원으로 제작. Protein G 정제 및 PBS buffer에 sodium azide 포함. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G8A5 |
| Immunogen | Purified recombinant fragment of human PAK3 (AA: 1–100) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787450 |
Product Specific Information
MA5-31827 has been tested in indirect ELISA.
Target Information
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. The alpha, beta, and gamma PAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to autophosphorylation. There are eight sites of autophosphorylation on gamma PAK, including Ser19, Ser141, and Thr402, and phosphorylation of Ser141 and Thr402 correlates with gamma PAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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