Thermo Fisher Scientific LIN7B Monoclonal Antibody (OTI1D12), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

LIN7B plays a role in establishing and maintaining asymmetric distribution of channels and receptors in polarized cells.
It forms membrane-associated multiprotein complexes that regulate delivery and recycling of proteins to correct membrane domains.
The LIN7–CASK–APBA1 complex may couple synaptic vesicle exocytosis to cell adhesion in the brain.
LIN7B ensures proper localization of GRIN2B (NMDA receptor subunit 2B) to neuronal postsynaptic density and helps localize Kir2 channels, GABA transporter (SLC6A12), and EGFR/ERBB family receptors to the basolateral membrane of epithelial cells.
It may also increase ACCN3 acid-evoked current amplitude by stabilizing the channel at the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.