Thermo Fisher Scientific LAT Polyclonal Antibody
LAT 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등에 사용 가능. Human LAT에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 기반 저장액 포함, 4°C 단기 및 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LAT. Recombinant protein control fragment (Product #RP-90454) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789577 |
Product Specific Information
Immunogen sequence:
HCHRLPGSYD STSSDSLYPR GIQFKRPHTV APWPPAYPPV TSYPPLSQPD LLPIPRSPQP LGGSHRTPSS RRDSDG
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell and FcεRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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