Thermo Fisher Scientific GTPBP4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GTPBP4. Recombinant protein control fragment (Product #RP-97043). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GTPBP4,uniProtId:Q9BZE4-1,ncbiNodeId:9606,antigenRange:277-366,antigenLength:634,antigenImageFileName:PA5-58862_GTPBP4_Q9BZE4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58862_GTPBP4_Q9BZE4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642269

Product Specific Information

Immunogen sequence: PLFINKPLIV VANKCDVKRI AELSEDDQKI FTDLQSEGFP VIETSTLTEE GVIKVKTEAC DRLLAHRVET KMKGNKVNEV LNRLHLAIPT

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

Target Information

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. Active in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.