Thermo Fisher Scientific ABHD4 Polyclonal Antibody
Human ABHD4 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ABHD4. Recombinant protein control fragment (Product #RP-88857) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637558 |
Product Specific Information
Immunogen sequence:
ADDLEQQSQG WLSSWLPTWR PTSMSQLKNV EARILQCLQN KFLARYVSLP NQNKIWTVTV SPEQNDRTPL VMVHGFGGGV GLWILNMDSL SARRTLHTFD LLGFGRSSRP AFPRDPEGAE DEFVTSIETW RETMGIPSMI LLGHSLGGF
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 97%
Target Information
The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and related diseases. Although they have unrelated sequences, various substrates, and different catalytic activities, they share the same canonical α/β hydrolase fold consisting of an eight-stranded parallel α/β structure. They are characterized by a catalytic triad composed of histidine, an acid, and a nucleophile.
Members of this superfamily are often drug targets for diseases such as diabetes, Alzheimer's disease, obesity, and blood clotting disorders.
- ABHD1: Involved in metabolizing smoking xenobiotics
- ABHD2: Participates in the development of atherosclerosis
- ABHD4: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE), involved in N-acyl ethanolamine biosynthesis
- ABHD5: Mutations contribute to Chanarin-Dorfman syndrome
- ABHD6: May play a role in nervous system metabolism and signaling
- ABHD14A: Possibly involved in granule neuron development
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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