Thermo Fisher Scientific GRF-1 Polyclonal Antibody
Thermo Fisher Scientific의 GRF-1 Polyclonal Antibody는 인간 ARHGAP35 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGAP35. Recombinant protein control fragment (Product # RP-104219) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791395 |
Product Specific Information
Immunogen sequence:
LVALTDGAVD VLDNDLSREQ LTEGEEIAQE IDGRFTSIPC SQPQHKLEIF HPFFKDVVEK KNIIEATHMY DNAAEA
Target Information
RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA, and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo. Cells must duplicate its protein components before division, requiring high levels of Pol III transcribed RNA and the presence of TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex (TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, TFIIIC63) is overexpressed in adenovirus-transformed and malignant cells, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes TBP, TFIIB-related factor 1 (TFIIIB90, BRF1), and TFIIIB, which are also upregulated in transformed cells. In many carcinomas, tumor suppressors RB and p53 are inactivated, affecting their ability to bind and inactivate TFIIIB function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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