Thermo Fisher Scientific MARCO Polyclonal Antibody
Rabbit polyclonal antibody targeting human MARCO protein. Validated for IHC, ICC/IF applications. High specificity and affinity purified. Suitable for cancer immunotherapy research and macrophage receptor studies.
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- PA564134
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- pk
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Thermo Fisher Scientific MARCO Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MARCO. Recombinant protein control fragment (Product #RP-103527) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643767 |
Product Specific Information
Immunogen sequence:
LNLQARLRVL EMYFLNDTLA AEDSPSFSLL QSAHPGEHLA QGASRLQVLQ AQLTWVRV
Highest antigen sequence identity to the following orthologs:
- Mouse: 52%
- Rat: 57%
Target Information
MARCO (Macrophage Receptor with Collagenous Structure), also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. It participates in the innate antimicrobial immune system by binding both Gram-negative and Gram-positive bacteria through its extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain.
The protein includes short cytoplasmic and transmembrane domains, an extracellular spacer domain, and a long collagenous domain. MARCO may form a trimeric molecule via association of the collagenous domains of three identical polypeptide chains.
Due to its expression in tumor-infiltrating macrophages and its role in suppressing immune responses within the tumor microenvironment, MARCO is considered a potential target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-64134_MARCO_Q9UEW3-1_Rabbit_PDP.jpeg, PA5-64134_MARCO_Q9UEW3-1_Rabbit.svg)
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