Thermo Fisher Scientific SWAP70 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
HKEARQRRKE LRKKQLAEQE ELERQMKELQ AANESKQQEL EAVRKKLEEA ASRAAEEEKK RLQTQVELQA RFSTELEREK LIRQQMEEQV AQKSSELEQY LQRVRELEDM YLKLQEALED ERQARQDEET VRKLQARLLE EESSKRAELE KWHLEQQQAI QTTEAEKQEL ENQRVLKEQA LQEAMEQLEQ LELERKQALE QYEEVKKKLE MATNKTKSWK DKVAHHEGLI RLIEPGSKNP HLITNWGPAA FTEAELEERE KNWKEKKTTE

Positive Samples: 293T, A549, LO2
Cellular Location: Cell membrane, Cell projection, Cytoplasm, Nucleus, Lamellipodium

Target Information

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3,4,5-trisphosphate binding. It acts as a link between recognition of specific switch regions and DNA break formation, participating in nuclear events and B-cell activation signaling. As a guanine nucleotide exchange factor (GEF), it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. SWAP70 mediates signaling of membrane ruffling, actin cytoskeleton dynamics, and cell protrusion, and is widely expressed in most tissues, especially mature B-cells, monocytes, and macrophages.

Safety and Usage

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.