Thermo Fisher Scientific POLR1A/RPA194 Polyclonal Antibody

Thermo Fisher Scientific POLR1A/RPA194 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:2,000–1:10,000
• Immunoprecipitation (IP): 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice.
Human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains:

• NH2-terminus contains an acidic region with a PEST domain and phosphorylated tyrosine residues.
• Central proline-rich domain.
• COOH-terminal SH2 domain.

SLP-76 functions as an adaptor or scaffold protein, playing a role in T cell development and activation, as well as mast cell and platelet function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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