Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Monoclonal Antibody (EP38Y)
EGFR Tyr1068 인산화 부위를 인식하는 Rabbit Monoclonal Antibody로, Human 시료에서 IHC(P), WB, ICC/IF 등에 사용 가능. 비결합형 액상 형태로 4°C 보관. 암 연구 및 EGFR 신호전달 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EP38Y |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGFR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_10977041 |
Product Specific Information
MA5-14485 targets Epidermal Growth Factor Receptor (EGFR) in IHC (P) applications and shows reactivity with Human samples.
The immunogen used is a synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGFR.
Target Information
EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression is associated with numerous cancers, making EGFR a key therapeutic target.
EGFR is encoded by the EGFR gene on chromosome 7 and belongs to the HER/ERbB family, which includes ERbB2, ERbB3, and ERbB4.
Binding of ligands such as EGF and TGF-α to the extracellular domain induces receptor dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
Overexpression has been observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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