Thermo Fisher Scientific DACT1 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: LSLVQKKTHP VRTNKPRTSV NADPTKGLLR NGSVCVRAPG GVSQGNSVNL
• Short-term storage: 2–8°C up to 1 week
• Long-term storage: -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  Cow 100%; Dog 93%; Guinea Pig 92%; Human 100%; Mouse 100%; Pig 100%; Rabbit 92%; Rat 100%; Zebrafish 85%

Target Information

Dapper homolog 1 (DACT1), an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism.
It interacts with Dvl through the DEP domain and the central/C-terminal regions of DACT1.
Human DACT1 gene is located at chromosomal region 14q23.1.
The protein prevents CTNNB1/beta-catenin degradation, enhancing transcriptional activation of Wnt target genes.
DACT1 is essential for normal notochord formation and is downregulated in hepatocellular carcinoma (HCC).
Expressed in human liver and various tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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