Thermo Fisher Scientific SETD7 Monoclonal Antibody (OTI2E3), TrueMAB
SETD7 단백질을 인식하는 마우스 단클론 항체로, Western blot과 유세포분석에 적합합니다. 인간 및 마우스 시료에 반응하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 안정한 PBS/BSA/glycerol 완충액에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E3 |
| Immunogen | Full length human recombinant protein of human SETD7 produced in HEK293 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activation of transcription. Has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K motif in substrate proteins. Monomethylates Lys-189 of TAF10, increasing its affinity for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and enhancing p53/TP53-mediated transcriptional activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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