Thermo Fisher Scientific CD86 Monoclonal Antibody (4B12)
인간 CD86 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 ELISA에 적합. PBS 기반 액상 형태이며, 보존제 무첨가. 항원제시 및 T세포 활성화 연구용으로 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B12 |
| Immunogen | CD86 (AAH40261.1, approx. 24–246 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
APLKIQAYFN ETADLPCQFA NSQNQSLSEL VVFWQDQENL VLNEVYLGKE KFDSVHSKYM GRTSFDSDSW TLRLHNLQIK DKGLYQCIIH HKKPTGMIRI HQMNSELSVL ANFSQPEIVP ISNITENVYI NLTCSSIHGY PEPKKMSVLL RTKNSTIEYD GIMQKSQDNV TELYDVSISL SVSFPDVTSN MTIFCILETD KTRLLSSPFS IELEDPQPPP DHI
Target Information
CD86 is one of two ligands (the other CD80) for CTLA4 and CD28.
It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation.
Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance.
CD86 is a type I membrane protein and member of the immunoglobulin superfamily, expressed by antigen-presenting cells.
It binds to CD28 and CTLA4 on T cells, providing positive or negative regulation of T-cell activation.
Alternative splicing results in two transcript variants encoding different isoforms of CD86.
Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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