Thermo Fisher Scientific PILRA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Mouse liver, Rat liver
• Immunogen sequence:
  QPSGSTGSGP SYLYGVTQPK HLSASMGGSV EIPFSFYYPW ELATAPDVRI SWRRGHFHRQ SFYSTRPPSI HKDYVNRLFL NWTEGQKSGF LRISNLQKQD QSVYFCRVEL DTRSSGRQQW QSIEGTKLSI TQGQQRTKAT TPAREPFQNT EEPYENIRNE G

Target Information

SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRα-mediated inhibition and PILRβ-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.