Thermo Fisher Scientific Phospho-FGFR1 (Tyr776) Polyclonal Antibody, Biotin
FGFR1 단백질의 Tyr776 인산화 부위를 특이적으로 인식하는 Biotin 결합 다클론 항체. Western blot, ELISA, IP에 사용 가능하며 사람 및 랫드 시료에 반응. 고순도 친화 크로마토그래피 정제, 안정한 보관을 위한 글리세롤 및 BSA 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 640–690 on human basic fibroblast growth factor receptor protein 1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor (FGFR) family, a group of four membrane-spanning tyrosine kinases (FGFR1–4) that serve as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, generating multiple variants that are differentially expressed during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are associated with several diseases, including Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are also linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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