Thermo Fisher Scientific TRAF5 Monoclonal Antibody (OTI7A3)
TRAF5 단백질을 표적하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. 인간 반응성, 비결합형 액상 형태이며, 고순도 친화 크로마토그래피로 정제되었습니다. TRAF5 신호전달 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 334–557 of TRAF5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725553 |
Target Information
Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated factors (TRAFs). TRAFs are cytoplasmic adapter proteins that mediate signal transduction from members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40) and the interleukin-1 receptor.
The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization.
TRAF5 is a 558-amino acid protein implicated in NF-κB and c-Jun N-terminal kinase/stress-activated protein kinase activation by TNF receptor family members, including CD27, CD30, CD40, and lymphotoxin-β receptor.
Targeted disruption of the TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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