Thermo Fisher Scientific ACER3 Polyclonal Antibody
ACER3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. 고순도 Affinity Chromatography 정제, PBS/glycerol buffer에 보관. 인체, 마우스, 랫트 반응성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ACER3 (Accession Q9NUN7), corresponding to amino acid residues T177–G227 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850852 |
Product Specific Information
Antibody detects endogenous levels of total PHCA.
Target Information
ACER3 is a protein coding gene. It encodes an endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain ceramides (C18:1, C20:1, C20:4), dihydroceramides, and phytoceramides into sphingoid bases such as sphingosine and free fatty acids at alkaline pH. These bioactive lipids mediate cellular signaling pathways regulating proliferation, apoptosis, and differentiation.
ACER3 controls sphingosine generation in erythrocytes, influencing sphingosine-1-phosphate levels in plasma. It may play a role in neuronal survival and function by maintaining ceramide and sphingosine-1-phosphate homeostasis in the brain. Additionally, it may modulate inflammatory responses by regulating proinflammatory ceramide levels in immune cells and tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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