Thermo Fisher Scientific RARS Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:25–1:100

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total Arginyl tRNA synthetase protein.

Target Information

The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. ArgRS (Arginyl-tRNA synthetase), also known as RARS or DALRD1, belongs to the class-I aminoacyl-tRNA synthetase family that includes LeuRS, ValRS, and IleRS. These proteins are large monomeric enzymes that catalyze the aminoacylation of tRNA by their cognate amino acid. ArgRS localizes to the cytoplasm and can form multisubunit complexes with other tRNA synthetases and auxiliary proteins. In the presence of ATP, arginine, and tRNA, ArgRS joins Arg to tRNA(Arg) at its synthetic active site. Two cytoplasmic forms of ArgRS have been described in mammals, differing by a 73 amino acid sequence required for assembly into the multisubunit complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.