Thermo Fisher Scientific SIRP alpha Monoclonal Antibody (03)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: Human SIRPA/CD172A

Target Information

SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells, and hematopoietic stem cells.
SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src, and insulin receptor, and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways.

Ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, mediating recruitment and activation of tyrosine phosphatases SHP-1 and SHP-2.

Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including inhibition of host cell phagocytosis by macrophages and bi-directional activation of T cells and dendritic cells.
SIRP alpha regulates cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones, and cell adhesion, playing a general role in various physiological and pathological processes.
Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.