Thermo Fisher Scientific TMPRSS12 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Guinea Pig: 86%
• Human: 100%
• Rabbit: 79%
• Rat: 86%

Target Information

TMPRSS12 (transmembrane protease serine 12) is a 348 amino acid single-pass membrane protein belonging to the peptidase S1 family and contains one peptidase S1 domain. The TMPRSS12 gene consists of approximately 45,000 bases and maps to human chromosome 12q13.12. Chromosome 12 encodes over 1,100 genes within 132 million bases, representing about 4.5% of the human genome. Several skeletal deformities, including hypochondrogenesis, achondrogenesis, and Kniest dysplasia, are linked to chromosome 12. Noonan syndrome, associated with cardiac and facial developmental defects, results from mutations in the PTPN11 gene (SH-PTP2). Chromosome 12 also contains a homeobox gene cluster essential for morphogenesis and a natural killer complex gene cluster encoding C-type lectin proteins involved in NK cell responses to MHC I interaction. Trisomy 12p is associated with facial developmental defects, seizure disorders, and variable severity depending on mosaicism extent.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.