Thermo Fisher Scientific ESRP2 Polyclonal Antibody
Human ESRP2 인식용 Rabbit Polyclonal Antibody로 IHC(P)에서 1:200–1:500 희석 범위로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS/glycerol buffer에 보존. ESRP2 관련 mRNA splicing 연구에 적합.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ESRP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641130 |
Product Specific Information
Immunogen sequence:
EFHMQHPSTC PARDLTVATM AQGLGLETDA TEDDFGVWEV KTMVAVILHL LKEPSSQLFS KPEVIKQKYE TGPCSKADVV DSETVV
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 87%
Target Information
RBM35A, also known as ESRP2, is an mRNA splicing factor that, together with its related protein RBM35A (ESRP1), coordinates an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation of genes such as FGFR2, CD44, CTNND1, and ENAH. They exert differential effects on protein translation via 5′ UTRs of mRNAs, suggesting that these proteins act as global regulators of an epithelial regulatory network. Loss of this ESRP-regulated splicing program induces phenotypic changes in cell morphology observed during epithelial–mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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