Thermo Fisher Scientific ITCH Polyclonal Antibody
Thermo Fisher Scientific의 ITCH Polyclonal Antibody는 인간 ITCH 단백질을 인식하는 Rabbit IgG 기반 항체로, WB, ICC/IF, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 안정적인 저장이 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ITCH. Recombinant protein control fragment (Product #RP-104867) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664412 |
Product Specific Information
Immunogen sequence:
GFTGASQNDDG SRSKDETRVS TNGSDDPEDA GAGENRRVSG NNSPSLSNGG FKPSRPPRPS RPPPPTPRRP ASVNGS
Highest antigen sequence identity to the following orthologs:
- Mouse: 78%
- Rat: 82%
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy.
The protein encoded by this gene interacts with atrophin-1 and is a closely related member of the NEDD4-like protein family.
This family of proteins are E3 ubiquitin-ligase molecules that regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling.
It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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