Thermo Fisher Scientific MAPK10 Polyclonal Antibody, FITC
MAPK10(JNK3) 인식을 위한 FITC 결합 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. WB, IHC, ELISA, IP 등 다양한 응용에 적합하며, 액상 형태로 -20°C에서 암소 보관합니다. 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공합니다.
- 카탈로그번호
- MAPK10-Y-FITC
- 판매단위
- pk
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Thermo Fisher Scientific MAPK10 Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 375–425 on human Mitogen-activated protein kinase 10 (JNK3, UniProt ID: P53779-1) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in the dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). It is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as integration points for multiple biochemical signals and are involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development.
Beta-arrestin 2 interacts with and stimulates phosphorylation of MAPK10 by MAP kinase kinase 4 (MAP2K4). Cyclin-dependent kinase 5 can phosphorylate and inhibit MAPK10 activity, potentially preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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