Thermo Fisher Scientific DNER Polyclonal Antibody
DNER 단백질을 인식하는 Rabbit Polyclonal Antibody로 Human, Mouse, Rat 시료에 반응. IHC, ICC/IF, ELISA 등 다양한 응용 가능. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 신경세포 내 DNER 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human DNER (amino acids 185–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNER (Delta-notch-like EGF-related receptor) is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. It contains ten extracellular EGF-like domains homologous to those of the Notch ligand Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells and mediates neuron-glia interaction during astrocytogenesis via direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This activates a Deltex-dependent Notch signaling pathway in Bergmann glia and regulates their morphogenesis. DNER is essential for the functional and morphological maturation of Bergmann glia. DNER-knockout mice exhibit motor discoordination and cerebellar morphogenesis retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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