Thermo Fisher Scientific DNER Polyclonal Antibody
DNER 단백질을 인식하는 Rabbit Polyclonal Antibody로 Human, Mouse, Rat 시료에 반응. IHC, ICC/IF, ELISA 등 다양한 응용 가능. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 신경세포 내 DNER 연구에 적합.
- 카탈로그번호
- BS-12115R
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DNER Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human DNER (amino acids 185–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNER (Delta-notch-like EGF-related receptor) is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. It contains ten extracellular EGF-like domains homologous to those of the Notch ligand Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells and mediates neuron-glia interaction during astrocytogenesis via direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This activates a Deltex-dependent Notch signaling pathway in Bergmann glia and regulates their morphogenesis. DNER is essential for the functional and morphological maturation of Bergmann glia. DNER-knockout mice exhibit motor discoordination and cerebellar morphogenesis retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.