Thermo Fisher Scientific CRYAB Polyclonal Antibody
CRYAB 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC(P)에서 1:50–1:200 희석 비율로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%)로 연구용에 적합합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 11–60 of Human Crystallin-alphaB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803124 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
- Alpha-crystallin: The largest class, composed of two primary gene products—alpha-A and alpha-B.
- Beta-crystallins: At least five different proteins.
- Gamma-crystallins: Monomeric, with at least five identified in bovine and rat lens.
Alpha-crystallin comprises about 40% of total lens protein composition. In addition to maintaining proper refractive index, it functions in a chaperone-like manner by preventing aggregate formation that may lead to cataract formation.
Phosphorylated states of alpha-crystallin occur in response to cellular stress and may serve structural control and protein maintenance functions. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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