Thermo Fisher Scientific COL27A1 Polyclonal Antibody

Applications

• Western Blot (WB): 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 86%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 85%; Pig: 86%; Rabbit: 86%; Rat: 85%; Sheep: 85%; Zebrafish: 85%

Target Information

This gene encodes a member of the fibrillar collagen family and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein is a preproprotein that includes:

• N-terminal signal peptide
• N-terminal propetide with thrombospondin N-terminal-like and laminin G-like domains
• Mature peptide forming the major triple-helical region
• C-terminal propeptide (COLFI domain) important for tissue growth and repair

Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been identified, though some full-length forms remain undetermined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.