Thermo Fisher Scientific TNFRSF11B Polyclonal Antibody
TNFRSF11B 단백질을 인식하는 Rabbit Polyclonal Antibody로서 Human 및 Mouse 시료에 반응. Western blot과 IHC(Paraffin)에서 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 안정적인 장기 보관 가능.
- 카탈로그번호
- PA534946
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: 참고 문헌 없음
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: 참고 문헌 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 1–67 of OPG (TNFRSF11B, UniProt ID: O00300-1, NCBI Node ID: 9606, Antigen Range: 1–67, Antigen Length: 401) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.85 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552295 |
Product Specific Information
- Recommended positive controls: human plasma, TNFRSF11B-transfected 293T
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The TNFRSF11B gene encodes a member of the TNF-receptor superfamily. The protein acts as an osteoblast-secreted decoy receptor that negatively regulates bone resorption. It binds specifically to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies in mice suggest roles in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants have been reported, but their full-length nature remains undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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