Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI10H3), TrueMAB
ABCB1 단백질을 인식하는 Mouse monoclonal 항체로, IHC(P)에서 1:150 희석 비율로 사용 가능. 인간 시료 반응성. Affinity chromatography로 정제된 액상 항체이며, PBS/BSA/glycerol buffer에 보관. 약물 내성 연구 및 ABC transporter 관련 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, involved in multidrug resistance. It acts as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, leading to decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs.
Additionally, this protein functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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