Thermo Fisher Scientific uPAR Recombinant Rabbit Monoclonal Antibody (HL2169)
Human uPAR을 인식하는 recombinant rabbit monoclonal antibody로, Western blot, IHC, ICC 등 다양한 분석에 사용 가능. HEK293 세포에서 발현되었으며 Protein A로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL2169 |
| Immunogen | Recombinant fragment of human uPAR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3092930 |
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule regulating cell-surface plasminogen activation, playing an important role in both normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a 22-residue signal peptide and a hydrophobic C-terminal portion, producing a highly glycosylated ~50 kDa protein in monocytes. This protein is anchored to the plasma membrane via a glycosyl-phosphatidylinositol linkage.
PLAUR (also known as uPAR) associates directly with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to the association between PLAUR and β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
uPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing up to a 33-fold increase in advanced-stage tumors compared with normal endometrial tissue. Elevated uPAR expression correlates with recurrence and mortality rates in endometrial cancer patients, making uPAR a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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