Thermo Fisher Scientific OAS3 Polyclonal Antibody
인간 OAS3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체. 바이러스 감염 저항 및 세포 성장 조절 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human OAS3. Recombinant protein control fragment (Product #RP-97704). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644932 |
Product Specific Information
Immunogen sequence:
LKGGCDSELV IFLDCFKSYV DQRARRAEIL SEMRASLESW WQNPVPGLRL TFPEQSVPGA LQFRLTSVDL EDWMDVSLVP AFNVLGQAGS GVKPKPQV
Ortholog sequence identity:
- Mouse: 58%
- Rat: 58%
Target Information
OAS3 is an interferon-inducible protein belonging to the 2-5A synthetase family. It may play a role in mediating resistance to viral infection, control of cell growth, differentiation, and apoptosis. OAS3 preferentially synthesizes dimeric 2’,5’-oligoadenylate molecules. GTP can serve as an alternative substrate. It binds double-stranded RNA and polymerizes ATP into PPP(A2’P5’A)N oligomers, which activate RNase L, cleaving single-stranded RNAs. The protein is expressed at high levels in placenta trophoblast.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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